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Department of Pharmacology and Toxicology

  1. About the Department
  2. Faculty
  3. Staff
  4. Research Facilities
  5. Projects Completed and Ongoing
  6. Contact Information


Department of Pharmacology and Toxicology has the facilities to carry out pharmacological screening of NCEs. The department can enter into project collaborations in regulatory toxicological testing, viz., acute, sub-chronic and chronic toxicity testing. The departmental research activities are concentrated in the following areas :

  • Opioid tolerance, supersensitivity and dependence mechanisms
  • Role of different subtypes of angiotensin receptors in hypertension and diabetic vascular complications
  • Understanding the mechanisms of diabetic complication and development of NIDDM & insulin resistance models in rodents; screening of synthetic and natural products for their antidiabetic activity
  • Role of alpha adrenoceptors in benign prostatic hyperplasia
  • Understanding the molecular mechanisms involved in ischaemic stroke
  • Evaluation of novel neuroprotective approaches for the treatment of cerebral ischemia
  • Development of animal models of cerebral ischemia
  • Understanding the mechanisms of diabetic neuropathy
  • Role of adenosine receptors subtypes in diabetic neuropathic pain
  • Evaluation of various neuroprotective approaches in diabetic neuropathy
  • Screening of NCEs for antileismanial activity.
  • Development of rat model for Alzheimer’s disease and screening of NCEs on learning and memory in rats
  • Production of monoclonal antibodies against Plasmodium yoelii nigeriensis antigens with the objective of characterization of protective antigens
  • Molecular mechanisms of protection, cytoadherence, immune evasion and red cell invasion in malaria
  • Biotherapeutics and chemotherapeutics evaluation of potential antimalarial, antitubercular, antileishmanial and antiamoebic agents in vitro and in vivo
  • Study of the opioids-induced bidirectional molecular signaling within the neuroimmune network with a view to develop new immunomodulators.
  • Histone modifications as targets for drug discovery
  • Molecular mechanism involved in toxicant and oxidative stress induced process of cell death



Pharmacology and Toxicology Research Facilities

Projects Completed and Ongoing

Projects Completed and Ongoing :

  • Drug abuse : Cause and effect relationship of opioid tolerance and dependence
  • Diabetes : In vitro & In vivo screening of NCEs (synthetic and natural) in IDDM, insulin resistance (HFD rats) Insulin Dependent Diabetes Mellitus and role of purinergic modulation of neuropathic pain in SID
  • Characterization of alpha – adrenoceptors in throacic aorta of Streptozotocin induced diabetes and high fat fed rats
  • Hypertension : Cause and effect relationship in the renal hypertension, Characterization of Angiotensin II receptors in renal and spontaneously hypertensive rats and High fat diet insulin resistant hypertensive rats
  • Studies on the Calcium Channels on angiotensin responses in diabetic rat vasculature
  • Evaluation of middle cerebral artery occlusion induced focal cerebral ischemia by assessing cerebral blood flow, blood gases, cerebral infarction, edema and neurological functions
  • Neuroprotective effect of poly (ADP) ribose polymerase inhibitor in focal ischemia
  • Evaluation of neuroprotective potential of antioxidants and specific peroxynitrite scavenger in focal ischemia
  • Neuroprotective potential of combination of poly (ADP) ribose polymerase inhibitors and antioxidants in focal ischemia
  • Identification of some surrogate markers of protective immunity in malaria by using hybridoma technology
  • Neuroprotective effect of MAPK inhibitors in focal ischemia
  • Evaluation of neuroprotective effect of peroxynitrite scavengers in global cerebral ischemia in gerbils
  • Role of poly (ADP) ribose polymerase inhibitors on H2O2 and peroxynitrite induced cell death in PC12 cell line
  • Pharmacological interventions targeted at adenosine receptors in diabetic neuropathic pain
  • To study the effects of adenosinergic agents on motor nerve conduction velocity and nerve blood flow in rats
  • Role of MAP kinase on diabetic neuropathy
  • Evaluation of free radical scavengers potential in diabetic neuropathy
  • Screening of NCEs for antileishmanial activity in hamster model of visceral leishmaniasis
  • Development of a new rigorous rodent malaria vaccination model for the evaluation of potential new immunoadjuvants
  • Molecular studies to determine the linkage between antigenic variation and drug-resistance in Plasmodium falciparum
  • Identification of some surrogate markers of protective immunity in malaria by using hybridoma technology
  • Colony-stimulating factors and interleukin-12 cascade during parasitic and mycobacterial infections by using mRNA assays and immunoassays
  • Study of the neuroimmunomodulatory effects of morphine and enkephalins in Leishmania donovani – and Plasmodium berghei-infected hosts, with special emphasis on the molecular and cellular mechanisms of protection
  • Determination of the role of acute-phase reactants in the interaction of Mycobacterium tuberculosis with macrophages, in vitro
  • Bioimmunotherapeutic and chemotherapeutic evaluation of potential new antimalarial, antitubercular, antileishmanial and antitrichomonal agents
  • Role of histone deacetylase inhibitors in Streptozotocin induced diabetes
  • Role of poly-ADP-ribose polymerase inhibitor and poly (ADP-ribose) glycohydrolase inhibitor in diabetic nephropathy

Contact Information