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Departments

Department of Pharmacology and Toxicology

Pharmacology and Toxicology

    Pharmacology and Toxicology


     pc@niper.ac.in

  • Department of Pharmacology and Toxicology has the facilities to carry out pharmacological screening of NCEs. The department can enter into project collaborations in regulatory toxicological testing, viz., acute, sub-chronic and chronic toxicity testing. The departmental research activities are concentrated in the following areas :

  • Opioid tolerance, supersensitivity and dependence mechanisms

  • Role of different subtypes of angiotensin receptors in hypertension and diabetic vascular complications

  • Understanding the mechanisms of diabetic complication and development of NIDDM & insulin resistance models in rodents; screening of synthetic and natural products for their antidiabetic activity

  • Role of alpha adrenoceptors in benign prostatic hyperplasia

  • Understanding the molecular mechanisms involved in ischaemic stroke

  • Evaluation of novel neuroprotective approaches for the treatment of cerebral ischemia

  • Development of animal models of cerebral ischemia

  • Understanding the mechanisms of diabetic neuropathy

  • Role of adenosine receptors subtypes in diabetic neuropathic pain

  • Evaluation of various neuroprotective approaches in diabetic neuropathy

  • Screening of NCEs for antileismanial activity.

  • Development of rat model for Alzheimer’s disease and screening of NCEs on learning and memory in rats

  • Production of monoclonal antibodies against Plasmodium yoelii nigeriensis antigens with the objective of characterization of protective antigens

  • Molecular mechanisms of protection, cytoadherence, immune evasion and red cell invasion in malaria

  • Biotherapeutics and chemotherapeutics evaluation of potential antimalarial, antitubercular, antileishmanial and antiamoebic agents in vitro and in vivo

  • Study of the opioids-induced bidirectional molecular signaling within the neuroimmune network with a view to develop new immunomodulators.

  • Histone modifications as targets for drug discovery

  • Molecular mechanism involved in toxicant and oxidative stress induced process of cell death


Projects (Completed and Ongoing)

Projects (Completed and Ongoing)
  • Drug abuse: Cause and effect relationship of opioid tolerance and dependence

  • Diabetes: In vitro & In vivo screening of NCEs (synthetic and natural) in IDDM, insulin resistance (HFD rats) Insulin Dependent Diabetes Mellitus and role of purinergic modulation of neuropathic pain in SID

  • Characterization of alpha – adrenoceptors in throacic aorta of Streptozotocin induced diabetes and high fat fed rats

  • Hypertension: Cause and effect relationship in the renal hypertension, Characterization of Angiotensin II receptors in renal and spontaneously hypertensive rats and High fat diet insulin resistant hypertensive rats

  • Studies on the Calcium Channels on angiotensin responses in diabetic rat vasculature

  • Evaluation of middle cerebral artery occlusion induced focal cerebral ischemia by assessing cerebral blood flow, blood gases, cerebral infarction, edema and neurological functions

  • Neuroprotective effect of poly (ADP) ribose polymerase inhibitor in focal ischemia

  • Evaluation of neuroprotective potential of antioxidants and specific peroxynitrite scavenger in focal ischemia

  • Neuroprotective potential of combination of poly (ADP) ribose polymerase inhibitors and antioxidants in focal ischemia

  • Identification of some surrogate markers of protective immunity in malaria by using hybridoma technology

  • Neuroprotective effect of MAPK inhibitors in focal ischemia

  • Evaluation of neuroprotective effect of peroxynitrite scavengers in global cerebral ischemia in gerbils

  • Role of poly (ADP) ribose polymerase inhibitors on H2O2 and peroxynitrite induced cell death in PC12 cell line

  • Pharmacological interventions targeted at adenosine receptors in diabetic neuropathic pain

  • To study the effects of adenosinergic agents on motor nerve conduction velocity and nerve blood flow in rats

  • Role of MAP kinase on diabetic neuropathy

  • Evaluation of free radical scavengers potential in diabetic neuropathy

  • Screening of NCEs for antileishmanial activity in hamster model of visceral leishmaniasis

  • Development of a new rigorous rodent malaria vaccination model for the evaluation of potential new immunoadjuvants

  • Molecular studies to determine the linkage between antigenic variation and drug-resistance in Plasmodium falciparum

  • Identification of some surrogate markers of protective immunity in malaria by using hybridoma technology

  • Colony-stimulating factors and interleukin-12 cascade during parasitic and mycobacterial infections by using mRNA assays and immunoassays

  • Study of the neuroimmunomodulatory effects of morphine and enkephalins in Leishmania donovani – and Plasmodium berghei-infected hosts, with special emphasis on the molecular and cellular mechanisms of protection

  • Determination of the role of acute-phase reactants in the interaction of Mycobacterium tuberculosis with macrophages, in vitro

  • Bioimmunotherapeutic and chemotherapeutic evaluation of potential new antimalarial, antitubercular, antileishmanial and antitrichomonal agents

  • Role of histone deacetylase inhibitors in Streptozotocin induced diabetes

  • Role of poly-ADP-ribose polymerase inhibitor and poly (ADP-ribose) glycohydrolase inhibitor in diabetic nephropathy